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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 205 departures available from sixteen of the world's leading cruise lines.
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102 Cruises (205 Cruise Departures)
8 Day Mediterranean with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 01 March 2026
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,724
OCEANVIEW
$1,803
BALCONY
$2,338
SUITE
$2,872
From 1,724
View Trip
11 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 16 May 2025
Countries Visited: Spain, Corsica, Sardinia, Sicily (+2 more), Greece, Italy
Exclusive Deal
INSIDE
$3,461
OCEANVIEW
$4,199
BALCONY
$5,062
SUITE
-
Save 1,310
From 2,938
View Trip
21 Day Spain, Morocco & Mediterranean Overture with Seabourn
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Gibraltar, Morocco (+4 more), Monaco, Italy, Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$15,755
SUITE
$28,714
From 15,755
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 April 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$758
SUITE
$1,104
From 758
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Santa Cruz de Tenerife to Genoa
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 07 November 2024
Countries Visited: Spain, Portugal, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$1,159
SUITE
-
From 1,159
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 October 2024
Countries Visited: Spain, Italy
Last Minute Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$540
SUITE
-
From 540
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$600
BALCONY
$728
SUITE
$1,421
From 600
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise

8 Days (7 Nights) Barcelona to Naples
Cruise Line: Princess
Ship: Sun Princess
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,745
OCEANVIEW
$2,132
BALCONY
$2,438
SUITE
$2,904
From 1,745
View Trip
8 Day A Journey Of Riviera Reveries And Italian Icons with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 26 August 2024
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,816
SUITE
$8,286
From 6,816
View Trip
10 Day A Journey from Barcelona to Rome with Explora Journeys
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 14 April 2025
Countries Visited: Spain, Sardinia, Tunisia, Sicily (+1 more), Italy
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,118
SUITE
$9,930
From 8,118
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 03 October 2024
Countries Visited: Spain, France, Italy
Exclusive DealExclusive Offer
INSIDE
$2,775
OCEANVIEW
$2,617
BALCONY
$2,747
SUITE
-
Save 3,234
From 2,358
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Countries Visited: Spain, Corsica, Sicily, Italy
Exclusive Deal
INSIDE
$1,536
OCEANVIEW
$1,684
BALCONY
$1,783
SUITE
$4,258
From 1,536
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Moon
Departure: 16 August 2024
Countries Visited: Spain, France, Italy, Sardinia
Essential FareDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$6,930
BALCONY
$8,019
SUITE
-
From 6,930
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sky, Viking Star, Viking Venus, Viking Vesta
Departures: Jan 2025 to Jul 2026
Countries Visited: Spain, France, Monaco, Italy (+2 more), Sicily, Croatia
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,697
SUITE
$14,350
Save 1,950
From 9,697
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 08 August 2024
Countries Visited: Spain, Italy, France
Exclusive Deal
INSIDE
$1,838
OCEANVIEW
$4,956
BALCONY
$2,034
SUITE
$9,340
Save 2,836
From 1,826
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$1,689
OCEANVIEW
$2,154
BALCONY
$2,600
SUITE
$3,314
Save 722
From 1,411
View Trip
6 Day France & Italy Cruise with Royal Caribbean
Cruise

6 Days (5 Nights) Barcelona to Ravenna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 12 May 2025
Countries Visited: Spain, Corsica, Italy, Sicily
Exclusive Deal
INSIDE
$1,531
OCEANVIEW
$1,953
BALCONY
$2,125
SUITE
$3,224
Save 524
From 1,284
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Barcelona to Livorno
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seaside
Departures: Oct 2024 to Apr 2025
Countries Visited: Spain, Tunisia, Sicily, Italy
Exclusive Deal
INSIDE
$853
OCEANVIEW
-
BALCONY
$1,062
SUITE
$1,458
From 1,062
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, France, Italy
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
8 Day Italy And Adriatic with Cunard
Cruise

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Countries Visited: Spain, Italy, Sicily, Greece (+1 more), Montenegro
Exclusive Deal
INSIDE
$1,684
OCEANVIEW
$1,882
BALCONY
$2,031
SUITE
$4,951
From 1,684
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Malaga to Genoa
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 10 November 2024
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$688
SUITE
-
From 688
View Trip
15 Day France, Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jul 2024 to Sep 2025
Countries Visited: Spain, Sardinia, Corsica, Sicily (+4 more), Italy, Greece, Montenegro, Croatia
Exclusive Deal
INSIDE
$2,578
OCEANVIEW
$2,776
BALCONY
$3,469
SUITE
$7,825
From 2,578
View Trip
8 Day A Journey from Barcelona to Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 09 September 2024
Countries Visited: Spain, France, Corsica, Italy
Unique EscapesExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,153
SUITE
$8,286
From 7,153
View Trip
31 Day Jewels Of Spain, Italy & France with Seabourn
Cruise

31 Days (30 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 11 July 2025
Countries Visited: Spain, Sardinia, France, Italy (+4 more), Monaco, Sicily, Malta, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$24,516
SUITE
$43,029
From 24,516
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Valencia to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$569
BALCONY
$678
SUITE
$1,242
From 569
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 08 September 2025
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 16 June 2025
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sardinia
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
13 Day Best Of The Med Voyage with Azamara Cruises
Cruise

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Pursuit
Departure: 13 July 2024
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
Circle Club Voyage
INSIDE
-
OCEANVIEW
-
BALCONY
$4,196
SUITE
$6,658
From 4,196
View Trip
13 Day Barcelona to Rome with Silversea
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 18 May 2025
Countries Visited: Spain, France, Monaco, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$16,087
Save 913
From 16,087
View Trip
10 Day Canary Islands And Madeira with MSC Cruises
Cruise

10 Days (9 Nights) Santa Cruz de Tenerife to Bari
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 23 March 2025
Countries Visited: Spain, Morocco, Sicily, Greece (+1 more), Italy
Save And Sail Offer
INSIDE
$1,748
OCEANVIEW
$2,194
BALCONY
$3,382
SUITE
$5,213
From 1,748
View Trip
Results: 61-90 of 102

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