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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? April, May and September are the most popular months to cruise between Spain and Italy and there are 211 departures available from sixteen of the world's leading cruise lines.
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114 Cruises (211 Cruise Departures)
8 Day Mediterranean with France & Italy with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ships: Sun Princess, Sun Princess
Departures: Jun 2024 to Aug 2025
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
$1,675
OCEANVIEW
$1,873
BALCONY
$1,982
SUITE
$2,667
From 1,675
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela
Departures: Aug 2024 to Aug 2026
Countries Visited: Spain, France, Italy, Greece (+1 more), Croatia
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,895
SUITE
$14,845
Save 1,118
From 9,895
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 21 April 2025
Countries Visited: Spain, France, Italy, Montenegro (+2 more), Croatia, Slovenia
INSIDE
$5,078
OCEANVIEW
$5,539
BALCONY
$6,229
SUITE
$7,953
From 5,078
View Trip
10 Day France Intensive Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 April 2025
Countries Visited: Spain, France, Corsica, Italy
INSIDE
$3,216
OCEANVIEW
$3,678
BALCONY
$4,368
SUITE
$6,091
From 3,216
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 September 2025
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
INSIDE
$6,090
OCEANVIEW
$6,552
BALCONY
$7,241
SUITE
$9,540
From 6,090
View Trip
8 Day Southern France and the Italian Riviera by Sea - with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 02 October 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,301
SUITE
$13,907
Save 159
From 8,301
View Trip
23 Day Scenic Strands & Havens with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Malaga to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 07 October 2025
Countries Visited: Spain, Morocco, Portugal, Tunisia (+4 more), Malta, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$9,807
OCEANVIEW
$10,569
BALCONY
$15,608
SUITE
$21,152
Save 2,073
From 9,807
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 04 March 2025
Countries Visited: Spain, Gibraltar, Corsica, Italy
INSIDE
$1,375
OCEANVIEW
-
BALCONY
$1,560
SUITE
$2,068
From 1,375
View Trip
11 Day French, Spanish & Italian Rivieras with Princess
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Island Princess
Departure: 05 August 2024
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
-
OCEANVIEW
$2,907
BALCONY
$3,907
SUITE
$3,983
From 2,907
View Trip
8 Day Mediterranean Spring with Oceania Cruises
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 06 May 2025
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
$4,129
OCEANVIEW
$4,357
BALCONY
$6,109
SUITE
$8,238
Save 2,031
From 4,129
View Trip
12 Day Around Italy's Boot: Venice Overnight with Holland America
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 September 2025
Countries Visited: Spain, France, Italy, Greece (+2 more), Croatia, Montenegro
Have It All Offer
INSIDE
$3,941
OCEANVIEW
$4,139
BALCONY
$5,278
SUITE
$7,159
From 3,941
View Trip
11 Day Greece, Turkey & Malta with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 25 May 2024
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
Exclusive Deal
INSIDE
$6,835
OCEANVIEW
-
BALCONY
-
SUITE
-
From 6,810
View Trip
6 Day France & Italy Cruise with Royal Caribbean
Cruise

6 Days (5 Nights) Barcelona to Ravenna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 12 May 2025
Countries Visited: Spain, Corsica, Italy, Sicily
Exclusive Deal
INSIDE
$1,522
OCEANVIEW
$1,986
BALCONY
$2,050
SUITE
$3,425
Save 589
From 1,319
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$600
BALCONY
$728
SUITE
$1,421
From 600
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Countries Visited: Spain, Corsica, Sicily, Italy
INSIDE
$1,635
OCEANVIEW
$1,783
BALCONY
$1,932
SUITE
$4,258
From 1,635
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+6 more), Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Venus, Viking Vesta
Departures: Jun 2024 to Jul 2026
Countries Visited: Spain, France, Monaco, Italy
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$4,450
SUITE
$6,925
Save 1,193
From 4,450
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise

8 Days (7 Nights) Barcelona to Naples
Cruise Line: Princess
Ship: Sun Princess
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
$1,746
OCEANVIEW
$2,132
BALCONY
$2,409
SUITE
$2,825
From 1,746
View Trip
31 Day Jewels Of Spain, Italy & France with Seabourn
Cruise

31 Days (30 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 15 April 2025
Countries Visited: Spain, Sardinia, France, Italy (+4 more), Monaco, Sicily, Malta, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$24,432
SUITE
-
From 24,432
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 April 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$530
OCEANVIEW
$679
BALCONY
$758
SUITE
$1,104
From 530
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Santa Cruz de Tenerife to Genoa
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 07 November 2024
Countries Visited: Spain, Portugal, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$1,159
SUITE
-
From 1,159
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, France, Italy, Corsica (+4 more), Sicily, Greece, Montenegro, Croatia
INSIDE
$3,867
OCEANVIEW
$4,263
BALCONY
$4,857
SUITE
$10,203
From 3,867
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 05 August 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,317
OCEANVIEW
$2,345
BALCONY
$2,664
SUITE
$4,343
Save 916
From 1,959
View Trip
8 Day A Journey from Barcelona to Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 09 September 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,816
SUITE
$8,286
From 6,816
View Trip
8 Day Western Mediterranean with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 30 September 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,002
OCEANVIEW
$2,617
BALCONY
$2,575
SUITE
$4,410
Save 774
From 1,650
View Trip
10 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Barcelona to Venice
Ship: Norwegian Pearl
Departure: 18 May 2024
Countries Visited: Spain, France, Italy, Sicily (+2 more), Greece, Croatia
INSIDE
$1,465
OCEANVIEW
$1,863
BALCONY
-
SUITE
-
From 1,465
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departures: Jul 2024 to Sep 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,160
OCEANVIEW
$2,624
BALCONY
$3,368
SUITE
$5,148
Save 873
From 1,657
View Trip
10 Day Canary Islands And Madeira with MSC Cruises
Cruise

10 Days (9 Nights) Santa Cruz de Tenerife to Bari
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 23 March 2025
Countries Visited: Spain, Morocco, Sicily, Greece (+1 more), Italy
Save And Sail Offer
INSIDE
$1,748
OCEANVIEW
$2,194
BALCONY
$3,382
SUITE
$5,213
From 1,748
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Monaco, Italy (+2 more), Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,913
From 8,424
View Trip
8 Day Spain, France & Italy Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 17 August 2024
Countries Visited: Spain, France, Italy
Exclusive Offer
INSIDE
$1,888
OCEANVIEW
$2,130
BALCONY
$2,451
SUITE
$5,677
Save 2,367
From 1,888
View Trip
23 Day Mediterranean Magic & Tyrrhenian Treasures with Seabourn
Cruise

23 Days (22 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 31 August 2024
Countries Visited: Spain, Sardinia, France, Italy (+4 more), Monaco, Sicily, Malta, Corsica
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$21,900
SUITE
-
From 21,900
View Trip
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